Sustained Ultrastructural Changes in Rat Hippocampal Formation after Repeated Electroconvulsive Seizures.

Sustained Ultrastructural Changes in Rat Hippocampal Formation after Repeated Electroconvulsive Seizures.

Related Articles

Sustained Ultrastructural Changes in Rat Hippocampal Formation after Repeated Electroconvulsive Seizures.

Int J Neuropsychopharmacol. 2020 Mar 26;:

Authors: Chen F, Danladi J, Wegener G, Madsen TM, Nyengaard JR

Abstract
BACKGROUND: Electroconvulsive therapy (ECT) is a highly effective and fast-acting treatment for depression used in the clinic. Its mechanism of therapeutic action remains uncertain. Previous studies have focused on documenting neuroplasticity in the early phase following electroconvulsive seizures (ECS), an animal model of ECT. Here, we investigate whether changes in synaptic plasticity and non-neuronal plasticity (vascular and mitochondria) are sustained 3 months after repeated ECS trial.
METHODS: ECS or sham treatment was given daily for one day or 10 days to a genetic animal model of depression: the Flinders Sensitive and Resistant Line (FSL/FRL) rats. Stereological principles were employed to quantify numbers of synapses and mitochondria, and length of microvessels in the hippocampus 24 hours after a single ECS, 3 months after 10 ECS treatments (one a day for 10 days) and sham-treatment. Brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) protein levels were quantified with immunohistochemistry. Results: A single ECS treatment significantly increased the volume of hippocampal CA1-stratum radiatum (SR), the total length of microvessels, mitochondria number and synapse number. The observed changes were sustained as shown in the multiple ECS treatment group analyzed 3 months after the last of 10 ECS treatments.
CONCLUSION: A single ECS caused rapid effects of synaptic plasticity and non-neuronal plasticity, while repeated ECS induced long-lasting changes in the efficacy of synaptic plasticity and non-neuronal plasticity at least up to 3 months after ECS.

PMID: 32215561 [PubMed – as supplied by publisher]

Full Text Link

0 replies

Leave a Reply

Want to join the discussion?
Feel free to contribute!

Leave a Reply

Your email address will not be published. Required fields are marked *